Warfarin Classification

(S)-Warfarin | C19H16O4 | CID 54688261 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more Also, what is the classification of Coumadin? Coumadin (warfarin) is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots. Coumadin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.. Similarly, what is the mechanism of action of warfarin Warfarin is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots. Warfarin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions. Warfarin may also be used for purposes not listed in this medication guide Warfarin is in a class of medications called anticoagulants ('blood thinners'). It works by decreasing the clotting ability of the blood. How should this medicine be used? Warfarin comes as a tablet to take by mouth Warfarin is known to be a teratogen and its use during pregnancy is contraindicated in the absence of high thrombotic risk. Label,19 Fetal warfarin syndrome, attributed to exposure during the 1st trimester, is characterized by nasal hypoplasia with or without stippled epiphyses, possible failure of nasal septum development, and low birth weight.

(S)-Warfarin C19H16O4 - PubChe

Warfarin Dabigatran Rivaroxaban Apixaban Edoxaban Betrixaban Generic Is there a generic available? Yes No No No No No FDA Approval When was this drug ˜ rst approved by the FDA? Pre-1982 Warfarin was ˜ rst used in humans in 1954, before the FDA regulated drugs. October 2010 July 2011 December 2012 January 2015 June 2017 FDA Approved Fo Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly it is used following ST-segment elevation. classification of drugs . first edition prepared by tariq ahmad department of pharmacy university of lahore . 732. tariq ahmad . • warfarin (generic, coumadin) 3) •thrombolytic agents . alteplase (tpa) • anistreplase • streptokinase • urokinase . 4) •treatment of bleeding WARFARIN: • has a NARROW THERAPEUTIC INDEX • is NEARLY COMPLETELY (99%) BOUND TO PLASMA ALBUMIN • is ELIMINATED BY HEPATIC METABOLISM (cytP450) Æ WARFARIN IS THE PROTOTYPE FOR DRUG-DRUG INTERACTIONS! 7. DROTRECOGIN ALFA is approved for use in disseminated intravascular coagulation or DIC (fatal complication of septic shock)

Warfarin inhibits all vitamin K-dependent coagulation factors; : an ticoagulants protein C and protein S have a relatively short half-life and are depleted more quickly than procoagulants factors II, IX, and X → increased factor V and VIII activity → initial hypercoagulable state → formation of microthrombi → vascular occlusion, tissue infarction, and blood extravasation; ; Warfarin • ADRs: Bleeding - epistaxis, haematuria, bleeding GIT Intracranial haemorrhage - Minor bleeding - Vit K (takes long) - Fresh blood transfusion or blood factors - Other ADRs: Alopecia, dermatitis and diarrhoea etc. • Contraindications: Same as heparin - Foetal warfarin syndrome: skeletal abnormality - hypoplasia of nose, eye socket, hand bones and growth retardatio You have a lot going on in your body that could make you feel bad, beside taking warfarin, and the warfarin is probably the least likely culprit. The amount of warfarin that any given individual has to take to stay within an INR range of 2.0 to 3.0 (which is probably what the doctors mean when they tell you they want you at 2.5) will vary, depending on how rapidly that person's body can metabolize and excrete the warfarin

Warfarin classification and annotation The periodic clinical gas of this progestin induction and its conditional secretes are extracellular at small hormone and play to begin evaluated. The most several assistant headaches energy up providing an crystalline dazed morning and a reasonable antagonist tremor Warfarin is an oral anticoagulant, a drug that inhibits the clotting of blood. It prevents the formation of blood clots by reducing the production of factors by the liver that promote clotting, factors II, VII, IX, and X, and the anticoagulant proteins C and S therapy with warfarin to a target INR of 3.0 (range, 2.5-3.5) is recommended. • For patients with caged ball or caged disk valves, therapy with warfarin to a target INR of 3.0 (range, 2.5-3.5) is.. Coumadin (warfarin) is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots. Coumadin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions. Coumadin may also be used for purposes not listed in this medication guide Inhibition of Warfarin Metabolism: 4: 3: sucralfate: decreased: Reduced Absorption of Warfarin: 5: 3: Sulfa Antibiotics: increased: Inhibition of Warfarin Metabolism: 1: 3: Sulfinpyrazone: increased: Inhibition of Warfarin Metabolism: 1: 2: tamoxifen: increased: Unexplained Mechanisms: 4: 0: telithromycin: increased: Inhibition of Warfarin Metabolism: 1: 4: temafloxacin: increase

What drug classification is warfarin? - FindAnyAnswer

  1. Generic Name: warfarin sodium. Brand Name: Apo-Warfarin (CAN), Coumadin, Gen-Warfarin (CAN) Classification: Oral anticoagulant, Coumarin derivative Pregnancy Category X Dosage & Route. Available forms :Tablets—1, 2, 2.5, 3, 4, 5, 6, 7.5, 10 mg; powder for injection—5.4 mg reconstitutes to 2 mg/m
  2. Anticoagulants, also known as blood thinners, help stop your blood from thickening, or clotting, when it's not necessary. Find out more about the different types of anticoagulants
  3. istered dose is recovered in urine. Very little warfarin is excreted unchanged in urine

warfarin classification. anticoagulant. mechanism of action of warfarin. vitamin k antagonist decreasing production of clotting factors II VII IX X. what is long term use of warfin used for. prevent clot formation. is warfarin a vitamin k agonist or antagonist. antagonist KRaj15 PLUS. Warfarin. *Warfarin Maintenance INR Goal 2.0 - 3.. *Warfarin Maintenance INR Goal 2.0 - 3.. *Warfarin Maintenance INR Goal 2.0 - 3.. *Warfarin Maintenance INR Goal 2.0 - 3.. Increase weekly dose by 10 - 15%; repeat INR within 7 days.. If falling or low on two or more occasions, increase weekly do Generally, the benefit of anticoagulation is prevention of or reduction of progression of a thromboembolic disease. Some indications for anticoagulant therapy that are known to have benefit from therapy include: Atrial fibrillation — commonly forms an atrial appendage clot. Coronary artery disease

large amounts of vitamin K may antagonize effects of warfarin. assess for signs of bleeding. therapeutic levels: PT 1.3-1.5, INR 2.5-3.5. instruct patient to report any signs of bleeding. patient should not drink alcohol. bleeding times need to be monitored frequently. vitamin K is antidote Find information on Warfarin (Coumadin, Jantoven) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF معتبر ترین سایت پیش بینی ورزشی و فوتبال ایرانی با درگاه مستقیم و ضریب بال

Warfarin Uses, Dosage, Side Effects - Drugs

  1. COUMADIN prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects
  2. Warfarin(Coumadin) generic is an anticoagulant, prescribed for deep venous thrombosis and pulmonary embolism. It reduces the formation of blood clots
  3. ases, and may increase lactic dehydrogenase activity. Interactions Drug: In addition to the drugs listed below, many other drugs have been reported to alter the expected response to warfarin; however, clinical.
  4. istration, time to onset of activity, method of monitoring, antidotes and use during pregnancy. 5. Understand why particular disease states and co-ad
  5. ishes within few hours- at different times by diff. factors But anticoagulant action starts in 1-3 days only.

© The British Society of Periodontology 2018 www.bsperio.org.uk. Stage IV . Title: Untitled-2 Author: studio Created Date: 20190107112041 AHFS Classification - Drug Assignments. The following tables describe changes to the AHFS Pharmacologic-Therapeutic Classification© that will be published in the 2021 edition of AHFS Drug Information® (February 1, 2021), as well as any new classes added after the publication of the 2020 edition. This is only a partial listing of the AHFS PTC Although regular testing of INR levels is essential for all people taking warfarin to maintain control of the INR, in practice, INR levels show considerable intra-patient variability. A study has demonstrated that a group of stable patients, on long-term warfarin treatment achieved the therapeutic range for INR approximately 55% of the time. 2 Drug-Drug Interactions . The effectiveness of a drug can often be reduced if the action of one drug diminishes the action of another. Since drugs are commonly classified by their mode and mechanism of action, any interaction affecting one drug will usually affect drugs of the same class, either by interfering with their absorption or the way in which the body metabolizes the drug Warfarin continues to be the most widely used oral anticoagulant but the use of the newer oral anticoagulants (dabigatran etexilate, rivaroxaban, edoxaban and apixaban) is increasing. Warfarin antagonises vitamin K (needed for the synthesis of clotting factors) and takes 2-3 days to exert its full effect

Warfarin should be avoided throughout the entire pregnancy especially during the first and third trimester. 4.3 Breast-feeding Warfarin does not induce an anticoagulant effect in the breast-fed infant and is therefore not contraindicated for the nursing mother. 4.4 Miscellaneous 4.4.1 Hypersensitivity to warfarin or any componen Warfarin, an oral agent in this class, reduces Vitamin K-dependent clotting factors. As a result, clotting process is prolonged. Two new oral agents, dabigatran and rivaroxaban, directly inhibits thrombin (last step in clotting process) and factor Xa, respectively. Heparin and antithrombin block formation of thrombin from prothrombin. Indication View Notes - warfarin from NURSING 247 at VCCS. Generic/Trade Names Classification Warfarin Apo-Warfarin, Coumadin, Jantoven, NovoWarfarin Coumarin derivative. Anticoagulant My Notes: HIGH ALERT Ma

Warfarin: MedlinePlus Drug Informatio

Warfarin patient education booklet (e.g. medication manufacturing company, private pathology or other) Guidelines for warfarin management in the community - 2 - 1. Guideline 1.1 General information Warfarin inhibits the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) and the antithrombotic factors, protein C and protein S.. 1. For warfarin patients, INR can be determined through point of care testing (POCT) or central laboratory test. All blood samplings for INR reading should be performed by relevant trained healthcare providers. 2. Renal and/or liver profile should be taken prior to scheduled appointment when needed Action Date Submission Supplement Categories or Approval Type Letters, Reviews, Labels, Patient Package Insert Note Url; 09/27/2019: SUPPL-38: Labeling-Package Insert, Labeling-Medication Guid Warfarin can cause very serious (possibly fatal) bleeding. This is more likely to occur when you first start taking this medication or if you take too much warfarin.. To decrease your risk for.

Warfarin, also called Coumadin, is an anticoagulant. In other words, it helps prevent the formation of blood clots. Surgical Wound Classification: Definition & Example Dosages :Adjust dosage according to the one-stage PT to achieve and maintain 1.5-2.5 times the control value or prothrombin activity 20%-30% of normal; PT ratio of 1.3-1.5 or INR of 2-3. IV use is reserved for situations in which oral warfarin is not feasible. Dosages are the same for oral and IV forms Warfarin is a commonly used medication for the prevention and treatment of venous thromboembolism. It can be challenging for both the patient and the prescriber to manage at times. Objective To describe the mechanism of action of warfarin, and to discuss the indications for warfarinisation, the risks associated with warfarin use, and some of. AHFS Pharmacologic-Therapeutic Classification 4:00 Antihistamine Drugs 4:04 First Generation Antihistamines 4:04.04 Ethanolamine Derivatives 4:04.08 Ethylenediamine Derivatives 4:04.12 Phenothiazine Derivatives 4:04.16 Piperazine Derivatives 4:04.20 Propylamine Derivatives 4:04.92 Miscellaneous Derivatives 4:08 Second Generation Antihistamine

Warfarin: Uses, Interactions, Mechanism of Action

Warfarin is used in agriculture and urban rodent control in the form of baits containing 0.025% active ingredient. The sodium salt is available at 0.5% concentrate for use at a final concentration of 0.05% in liquid base. Warfarin is also used as a drug for the treatment of thromboembolic disease in humans. 2 Warfarin is used to treat blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE) and/or to prevent new clots from forming in your body.Preventing harmful blood clots helps to reduce the risk of a stroke or heart attack.Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm (atrial fibrillation), heart valve replacement. CLASSIFICATION OF ORAL ANTICOAGULANTS Coumarin Derivatives e.g. Warfarin, Acenocoumarol (Acitrom) Indandione Derivatives e.g. Phenindione, Anisindione Newer anticoagulants Direct thrombin inhibitors Dabigatran etexilate (Pradaxa) Direct factor Xa inhibitors Rivaroxaban (Xarelto) Apixaban Edoxaban (DU-176b) Betrixaban. 8

COUMADIN (warfarin sodium) tablets and COUMADIN (warfarin sodium) for injection contain warfarin sodium, an anticoagulant that acts by inhibiting vitamin K ⌈dependent coagulation factors. The chemical name of warfarin sodium is 3- (α-acetonylbenzyl)-4-hydroxycoumarin sodium salt, which is a racemic mixture of the R - and S -enantiomers The main side effect of warfarin is bleeding. While the risk of major bleeding is low, you need to be aware of potential problems. For example, you might have trouble stopping the bleeding from a cut on your hand or a nosebleed. More-serious bleeding may occur inside the body (internal)

Warfarin sodium is an anticoagulant medication. Anti means against and coagulant means causing blood clotting. Warfarin controls the way that blood clots (thickens into a lump) inside your blood vessels. The brand names of warfarin are Coumadin® and Jantoven®. Cleveland Clinic is a non-profit academic medical center 1.3 BCS Classification - TPD use only. 3.0 Test product. 3.1 Formulation. Tabulate the composition of each product strength using the table below. For solid oral dosage forms the table should contain only the ingredients in the product core. A copy of the table should be filled in for the coating ingredients, if any Warfarin classification Order generic warfarin 1 mg the doctor only Warfarin class, warfarin classification - Discount prices, No prescription needed ‒ www.rammedearthliving.com.au Friday, 05 April 201 Mechanism of Action. inhibit epoxide reductase (hydrase), which is the most important enzyme responsible for regenerating reduced vitamin K. NOT DIRECT INHIBITION of the post-translational modification step whereby carboxylated Gla residues are generated. ultimately decreases synthesis of the vitamin K-dependent clotting factors II, VII, IX, X

Warfarin (sold under Coumadin and others) was originally used as rat poison, where it caused internal bleeding and death. This anticoagulant effect was then harnessed for medicinal purposes. Warfarin is now one of the go-to medicines for patients with thrombosis. Warfarin was first approved for medical use in the United States in 1954 PO (Adults): 2-5 mg/day for 2-4 days; then adjust daily dose by results of INR.Initiate therapy with lower doses in geriatric or debilitated patients or in Asian patients or those with CYP2C9*2 and/or CYP2C9*3 alleles or VKORC1 AA genotype.. PO (Children >1 mo): Initial loading dose- 0.2 mg/kg (maximum dose: 10 mg) for 2-4 days then adjust daily dose by results of INR, use 0.1 mg/kg if.

Warfarin (Coumadin ) is a blood thinner that helps prevent clots from forming in the blood vessels and the heart. Foods high in vitamin K can affect the way Coumadin works in your body. The more vitamin K rich foods you eat, the lower the levels of Coumadin in you View Homework Help - WARFARIN (COUMADIN).doc from BUSINESS 3403 at University of Phoenix. CLIENT MEDICATION FORM Trade & Generic Names Coumadin/Warfarin Classification Func. Class Warfarin was the first anticoagulant rodenticide. 1 It was registered for use in 1950. 4 Warfarin was discovered in moldy sweet clover that had made a herd of cattle sick. Researchers found that a fungus had converted a chemical that occurs naturally in the clover to a more toxic chemical. 9 Warfarin was widely used until many rodents began to become resistant to it warfarin's effects on people is available, animal toxicity studies were not needed or required. Warfarin's toxicology and mechanism of action, as well as the methods for treating warfarin overdose in humans, are well understood. A synthetic analogue of Vitamin K, warfarin is a member of the coumarin family of blood anticoagulant chemicals

Classification, pathophysiology, and mechanisms of AF: key points. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. AF is usually classified according to its temporal pattern as paroxysmal, persistent, or permanent Media in category Warfarin The following 29 files are in this category, out of 29 total Warfarin sodium therapy usually starts within 72 hours of enoxaparin injection. Outpatient treatment of acute DVT without pulmonary embolism when administered with warfarin sodium. Adults: 1 mg/kg S.C. every 12 hours for 5 to 7 days until therapeutic oral anticoagulant effect (INR 2 to 3) has been achieved. Warfarin sodium therapy usually.

Management of antithrombotic agents in patients undergoing

Warfarin - Wikipedi

Warfarin is the cornerstone of medical therapy in stroke prevention and has been shown to be an effective anticoagulant. Click here for the Warfarin Care Plan.. It is a double-edged sword in that it prevents stroke but can predispose patients to fatal bleeding if the dosage is too high a. Anticoagulant drugs retard coagulation and thereby prevent he occurrence or enlargement of a thrombus (Figure 14-13). These drugs include heparin sodium, given intravenously, and warfarin sodium (Coumadin) in injectable and oral form Begin therapy with warfarin at a dose of 5 mg (or less) per day with dosage adjustments based on serial INR determinations. For Patients on Heparin (unfractionated or low molecular weight): Because the anticoagulant effect of warfarin is delayed, heparin is administered for rapid anticoagulation On basis of what have been done on herb-warfarin interactions, the current review aims at complementing the missing points from previous studies as summarized below: (i) classification of clinical significance: life threaten, bleeding, INR change, and so forth; (ii) assessment of evidence reliabilities: highly probable, probable, possible, and.

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• B. Warfarin with goal INR 2.0-3.0, clopidogrel 75 mg daily • • WOEST showed a significant reduction in the primary endpoint of bleeding events, the secondary endpoint of death, MI, revascularization, stroke, stent thrombosis, and even the endpoint of all-cause mortality for patients receiving a coronary stent who require anticoagulatio CLASSIFICATION OF ORAL ANTICOAGULANTS Coumarin Derivatives e.g. Warfarin, Acenocoumarol (Acitrom) Indandione Derivatives e.g. Phenindione, Anisindione Newer anticoagulants Direct thrombin inhibitors Dabigatran etexilate (Pradaxa) Direct factor Xa inhibitors Rivaroxaban (Xarelto) Apixaban Edoxaban (DU-176b) Betrixaban. 8 An INR test meter is a portable, battery-operated meter, used to monitor patient response to warfarin. The meter has a screen that displays results, and an opening for meter-specific test strips Warfarin is a blood-thinning medication that helps treat and prevent blood clots. There is no specific warfarin diet. However, certain foods and beverages can make warfarin less effective in preventing blood clots. It's important to pay attention to what you eat while taking warfarin. One nutrient that can lessen warfarin's effectiveness is. Warfarin was the mainstay of oral anticoagulant therapy until the recent discovery of more precise targets for therapy. In recent years, several new oral anticoagulants (NOACs) have been introduced and more drugs are Drug and indication Renal function classification Norma

** It may be necessary to hold warfarin longer than 5 days for select patient populations (e.g. elderly, liver dysfunction, low dose requirements, target INR of 3.0 - 4.0, supratherapuetic INR) - At the discretion of the MD performing the procedure, it may be appropriate to check an INR the day before procedure t Classification of blood thinners: Anticoagulants and antiplatelet drugs can be classified according to their mechanism of action. Anticoagulants Anticoagulants interfere with various clotting factors in the coagulation process to slow down the process. Take warfarin once a day at the same time each day as prescribed, usually in the evening The proportion treated with warfarin in this subgroup was only 33%, and this proportion decreased markedly >80 years of age; however, this figure is based on individual patients and with very few individuals aged >90 years. Warfarin was taken by 57.8% of patients with AF with ICH compared with 29.9% of patients with AF with ischemic stroke The most notorious food-drug interaction regarding warfarin occurs with green, leafy vegetables due to their rich vitamin K content. Warfarin, by its mechanism of action, interferes with the synthesis of vitamin K-derived clotting factors. 3 Increasing vitamin K intake will result in more clotting factors, reducing the efficacy of warfarin Descriptions. Warfarin is used to prevent or treat blood clots, including deep venous thrombosis or pulmonary embolism. It is also used for blood clots that may be caused by certain heart conditions, open-heart surgery, or after a heart attack. Warfarin is an anticoagulant (blood thinner) that decreases the clotting ability of the blood

Oral anticoagulants - Knowledge @ AMBOS

fluid in the covering of the heart or pericardium. a hemorrhage in the brain. balloon-like swelling of an artery of the brain. bulge and tear of the aorta blood vessel wall. a cholesterol embolism. The most commonly prescribed anticoagulant is warfarin. Newer types of anticoagulants are also available and are becoming increasingly common. These include: rivaroxaban (Xarelto) dabigatran (Pradaxa) apixaban (Eliquis) edoxaban (Lixiana) Warfarin and the newer alternatives are taken as tablets or capsules Dosage/Direction for Use. Syr Adult & childn >12 yr 1 tsp (5 mL). Childn 3-12 yr ½ tsp (2.5 mL). Drops Infant 6 mth-2 yr 0.6 mL. All doses to be taken once daily. Click to view PedZINC Plus C detailed prescribing information

Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. It is characterized by an irregular and often rapid heartbeat (see the image below) Introduction. Warfarin is the most widely used oral anticoagulant worldwide. Due to its narrow therapeutic window and large interpatient variability, warfarin dosing remains challenging [].The consequence of incorrect warfarin dosing can be devastating, predisposing the patient to thrombosis in the case of under-dosing or bleeding in the case of overdosing

Anticoagulants - SlideShar

Background Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor... On warfarin, needing routine INR blood monitoring was very inconvenient and it became a long and extensive process. I asked my doctor to switch me to PRADAXA, with its twice a day dose schedule. PRADAXA requires no INR testing, which is much more convenient for me. - Gregg, 61 *Warfarin is also known as Coumadin ® or Jantoven ® • Warfarin • Warfarin: Management of Out-of-Range INR REFERENCES: Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361(12):1139-1151. Gage BF, et al. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation Anticoagulant Rodenticides (Warfarin and Congeners) Anticoagulant rodenticides inhibit the enzyme vitamin K epoxide reductase, which normally reactivates vitamin K, a crucial component in a number of normal clotting factors, after those factors are consumed in normal maintenance. Potentially dangerous to all mammals and birds, anticoagulant. The doses after day 5 were determined according to usual local clinical practice. In the control group, patients 75 years of age or younger received 10 mg of warfarin on day 1, 5 mg on day 2, and.

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warfarin classification - MedHel

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Warfarin classification and annotatio

ATC/DDD Index 2021. A searchable version of the complete ATC index with DDDs is available below. The search options enable you to find ATC codes and DDDs for substance name and/or ATC levels. In your search result you may choose to show or hide the text from the Guidelines for ATC classification and DDD assignment linked to the ATC level Pharmacodynamic Drug Interaction Between Warfarin and Amoxicillin-clavulanic Acid (INWARA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government Study Exam 1 Pharm II flashcards from Elise Wardrop's class online, or in Brainscape's iPhone or Android app. Learn faster with spaced repetition

warfarin (Coumadin, Jantoven) Side Effects, Dosage & Use

Coumadin: Uses, How to Take, Side Effects - Drugs

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